Induce mitophagy
Web12 feb. 2015 · Parkin-mediated mitophagy induction associates with reduced levels of mitochondrial outer membrane proteins including TOM20 through proteasome-mediated protein degradation (34, 35). Deficits in proteasome activity and inhibition of ubiquitin-dependent protein degradation have also been indicated in AD ( 59–61 ), which may … WebDeferiprone (DFP) induces mitophagy more vigorously than deferoxamine (DFO) and deferasirox (DFX) in human liver cells An iron chelator, DFP, has been shown to induce mitophagy in vitro (Allen et al, 2013). First, we assessed which iron chelator triggers mitophagy most vigorously among the three iron chelators (DFP, DFO, and DFX).
Induce mitophagy
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WebViruses induce mitophagy to mitigate type i interferon responses. Following infection, invading microorganisms are sensed by pattern-recognition receptors (PRRs) of the innate immune system in the host cells [Citation 59]. PRRs that bind conserved pathogen-associated molecular patterns (PAMPs) trigger immune signaling pathways. WebTo date, there is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative …
Web28 sep. 2024 · It is worth noting that HCV and CSFV induce mitophagy to attenuate the IFN response. Herein, we also determined that the NFKB signaling pathway become activated when LDHB is inhibited via specific siRNA and that expression of the associated pathway proteins, RELA and IKBIA, are upregulated concomitant with a release in … WebMitophagy is a key process regulating mitochondrial quality control. Several mechanisms have been proposed to regulate mitophagy, but these have mostly been studied using …
Web1 dec. 2012 · Conditions that lead to a general induction of bulk autophagy, such as starvation or serum deprivation, are known to induce also mitophagy. However, it is not clear whether in these cases the molecular steps for mitophagy are identical to situations when primarily compromised mitochondria have to be recognized and degraded selectively. Web3 jun. 2024 · Studies on the role of non-transcribed microRNAs in mitophagy reveal that inhibiting miR-204 expression can efficiently inhibit AD progression by improving mitophagy . Pharmacologic induction of mitophagy, such as with the use of urolithin A, actinonin, or nicotinamide mononucleotide, has beneficial effects on Aβ and Tau pathologies and ...
Web20 mei 2024 · Mitophagy can be triggered by a pathogen infection (Oh, et al., 2024). For example, M. tuberculosis and M. bovis were reported to cause similar metabolic rewiring …
WebIn summary, zinc induces mitophagy through PINK1 and Beclin1 via ERK leading to the prevention of mitochondrial superoxide generation in the setting of H/R. Clearance of … rear admiral herve hamelinWeb2 feb. 2024 · Mitochondrial dynamics is essential for the maintenance of cell homeostasis. Previous studies have shown that porcine circovirus 2 (PCV2) infection decreases the mitochondrial membrane potential and causes the elevation of reactive oxygen species (ROS), which may ultimately lead to mitochondrial apoptosis. However, whether PCV2 … rear admiral jaswinder singhWeb13 nov. 2024 · As expected, the number of mitochondria increased when treated with Lys05 or CQ under hypoxia, but not under normoxia, suggesting that mitophagy is occurring only under hypoxic conditions. Baf A1 caused an increase in mitochondria under both hypoxia and normoxia, suggesting that Baf A1 can both induce mitophagy and block … rear admiral h.w. howard iiiWebEffects of mitophagy were detected in Parkin-overexpressing 293T cells. Results: Our data suggested that epoxycytochalasin H could strongly reduce cell proliferation and induce apoptosis in ovarian cancer cell line A2780. Epoxycytochalasin H induced apoptosis through mitochondrial injury, mitophagy, and endoplasmic reticulum stress. rear admiral ian richardsWeb9 mei 2024 · Proteins related with mitophagy (Atg families including LC3) or mitochondrial biogenesis (PGC-1α) can be deacetylated to induce mitophagy or mitochondrial … rear admiral howard nswWeb26 dec. 2024 · Mitophagy is a selective autophagy process that specifically removes damaged mitochondria via general autophagy. The two major recessive Parkinson's disease genes PINK1 and Parkin play essential roles in mitophagy initiation, increasing the interest in mitophagy in both basic and translational research over the past 10 years. rear admiral iain lowerWebprotection by inducing mitophagy via the p62-dependent pathway (Kim et al., 2016). In addition, the loss of Parkin, a key player in mitophagy, improves the host antiviral immune response by activating the NLRP3 inflammasome, suggest-ing that mitophagy activation is critical for the regulation of antiviral immunity (Li et al., 2024). rear admiral hugh w. howard iii