Web1 mei 2009 · In all cells of the podocyte lineage in Nphs1-Cre/ROSA26 mice, the lacZ marker gene is irreversibly activated after Cre-mediated excision by nephrin promoter activation.Thus, podocyte lineage cells are theoretically stably labeled with lacZ, even when they are injured and lose podocyte markers. Web14 jan. 2009 · The nephrin–podocin complex is the main constituent of slit diaphragms. However, the molecular mechanisms regulating these proteins to maintain the slit diaphragms are still largely unknown. Here, we demonstrate that the PAR3–atypical …

An essential role of the universal polarity protein, aPKClambda, on …

WebView Tg(Nphs1-cre)#Seq allele: origin, molecular description, gene associations, and references. WebThe NPHS1 gene mutated in NPHS1 children has recently been identified. The gene codes for nephrin, a cell-surface protein of podocytes. Two mutations, named Fin-major and Fin-minor, have been found in over 90% of the Finnish patients. infamous places

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Web29 sep. 2024 · The animal model experimental platform has more than 10 different strains of transgenic tool mice such as Cag-CRE, Tek-CRE, Aqp2-CRE, Nphs1-CRE, TRE-CRE, rtTA-Nephrin and Ggt-CRE, and can construct glomeruli Nephritis, diabetic nephropathy, ischemia-reperfusion injury and unilateral ureteral obstruction and other animal models … Web27 aug. 2024 · Nephrotic syndrome (NS) encompasses a triad of clinical features including proteinuria (≥3 g/24 h), low serum albumin (hypoalbuminemia), and edema, and is often accompanied by complications such as secondary hyperlipidemia, thrombotic events, … WebIntroduction: Few studies have addressed the genetic spectrum of NPHS1 variants in Chinese children with nephrotic syndrome. In this multicenter study, the clinical manifestations and features of NPHS1 variants in Chinese children with nephrotic … logistics truck sizes